Science
How a DNA-sensing biomolecule is inactivated? – Tech Explorist
Scientists at EPFL and the Friedrich Miescher Institute have used cryo-electron microscopy to explain how a DNA-sensing biomolecule that is key to our innate immunity…
The DNA sensor cyclic GMPAMP synthase (cGAS) initiates innate immune responses following microbial infection, cellular stress, and cancer. Upon activation by double-stranded DNA, cytosolic cGAS produces biochemical reactions that activate the body’s so-called “innate” immune system.
cGAS is also present inside the cell nucleus, replete with genomic DNA, where chromatin has been implicated in restricting its enzymatic activity. However, the structural basis for inhibition of cGAS by chromatin remains…
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