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A light switch for cutting DNA – Scienceline

How Tokyo researchers made a CRISPR gene-editing technology, in 2015, that can be controlled with a light switch.

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From the outside, it must have looked like a dull experiment: a scientist hunched over a plastic dish in a pitch-black room. The door is closed to block out light from the hallway. In the dish, invisible to the human eye, lie thousands of human cells. The scientist flips a switch. A blue light flickers on, illuminating the cells. It looks, quite frankly, like nothing has happened. But inside of each cell, a remarkable change transpires: their genomes have been cut by a light-controlled DNA editor.

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