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Cholesterol in the plasma membrane is essential for SARS-CoV-2 entry and syncytia formation – News-Medical.Net
A preprint indicates that SARS-CoV-2 requires cholesterol to accomplish entry into the host cells and membrane fusion.
A provoking preprint that appeared recently on the bioRxiv* server indicates that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires cholesterol to accomplish entry into the host cells and membrane fusion. This could have significant implications for therapeutic strategies to combat the current coronavirus disease 2019 (COVID-19) pandemic.
The virus attaches to host cells via the trimeric spike glycoproteins that stud its lipid envelope. The spike attaches to the host cell…
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