Health
Found: a genetic link to molecular events that precede symptoms in Alzheimer’s disease – Newswise
Tufts researchers find a key mutation causing abnormal transport of BACE1, the enzyme responsible for processing the Alzheimer’s disease-linked amyloid protei
Newswise — BOSTON (Nov. 18, 2020, 2:00 p.m. ET)—Researchers at Tufts University School of Medicine have discovered a molecular mechanism that causes a “traffic jam” of enzymes traveling up and down neuronal axons, leading to the accumulation of amyloid beta – a key feature and cause of Alzheimer’s disease. The enzyme, BACE1, gets backed up, causing the axons to clog and swell because of the increased production of the toxic amyloid protein.
The study, published today in Science Translational Medicine,…
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