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Why does the novel Coronavirus Spike Protein interact so strongly with the human ACE2? A thermodynamic answer – DocWire News
Chembiochem. 2020 Oct 20. doi: 10.1002/cbic.202000455. Online ahead of print.ABSTRACTThe SARS-CoV-2 pandemic is the biggest health concern today, but
Chembiochem. 2020 Oct 20. doi: 10.1002/cbic.202000455. Online ahead of print.
ABSTRACT
The SARS-CoV-2 pandemic is the biggest health concern today, but until now there are no treatments. One possible drug target is the Receptor Binding Domain (RBD) from the Coronavirus’ Spike Protein, which recognizes the human angiotensin-converting enzyme 2 (hACE2). Our in silico study discusses crucial structural and thermodynamic aspects of the interactions involving RBDs from the SARS-CoV and SARS-CoV-2 with…
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