Health
Hypoxic exosomes promote stemness in EWS sarcoma, indicates study – News-Medical.net
The cover for issue 40 of Oncotarget features Figure 5, “miR-210 silences the proapoptosis member CASP8AP2,” by Kling, et al. which reported that hypoxic Ewing’…
Reviewed by Emily Henderson, B.Sc.Oct 9 2020
The cover for issue 40 of Oncotarget features Figure 5, “miR-210 silences the proapoptosis member CASP8AP2,” by Kling, et al. which reported that hypoxic Ewing’s sarcoma cells release exosomes that promote sphere formation, a stem-like phenotype, in EWS cells by enhancing survival.
Analysis of the hypoxic exosomal miRNA cargo identified a HIF-1α regulated miRNA, miR-210, as a potential mediator of sphere formation in cells exposed to hypoxic exosome…
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