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In higher organisms, detection of DNA in the cytoplasm leads to an immune reaction. The enzyme that senses DNA is also “out of place” in the nucleus, but
In higher organisms, detection of DNA in the cytoplasm leads to an immune reaction. The enzyme that senses DNA is also “out of place” in the nucleus, but DNA has no such effect. LMU researchers are now reporting why.The bulk of DNA in cells of higher organisms is confined to the nucleus, while all other organic DNA is restricted to specific intracellular compartments in the cytoplasm. Thus the appearance of DNA in the soluble phase of the cytoplasm is interpreted by the innate immune system as a…
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