Health
Whole-Genome Sequencing Makes a Case in Leukemia Study – MedPage Today
More actionable alterations detected in myeloid malignancies versus cytogenetics
Whole-genome sequencing (WGS) provided more information on the genetics of myeloid malignancies and changed the risk category in 16% of patients in a comparison with standard cytogenetic analysis.
WGS identified all of the translocations and copy-number alterations detected by cytogenetic analysis plus an additional 40 abnormalities in 235 patients. In a prospective evaluation involving 117 consecutive patients, WGS provided new genetic information in a fourth of patients, and the median wait for…
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