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Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases – The BMJ

Objective To assess the risks of breast cancer associated with different types and durations of hormone replacement therapy (HRT).Design Two nested case-control…

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Abstract
Objective To assess the risks of breast cancer associated with different types and durations of hormone replacement therapy (HRT).
Design Two nested case-control studies.
Setting UK general practices contributing to QResearch or Clinical Practice Research Datalink (CPRD), linked to hospital, mortality, social deprivation, and cancer registry (QResearch only) data.
Participants 98611 women aged 50-79 with a primary diagnosis of breast cancer between 1998 and 2018, matched by age, general…

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