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Type 1 conventional dendritic cell fate and function are controlled by DC-SCRIPT – Science
Dendritic cells (DCs) initiate diverse and context-specific adaptive immune responses. Zhang et al . define a role for the transcription factor DC-SCRIPT in the…
INTRODUCTION
Dendritic cells (DCs) are a heterogeneous and functionally distinct group of immune cells that are pivotal to adaptive immune responses (1). In the steady state, DCs encompass conventional DC (cDC) and plasmacytoid DC (pDC) subsets. cDCs are highly potent at taking up, processing, and presenting antigens to T cells, orchestrating their expansion, functional polarization, and effector activity. In contrast, pDCs have a limited capacity to promote T cell expansion but have the characteristic…
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