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Two Anti-viral Enzymes Transform Pre-Leukemia Stem Cells into Leukemia – UC San Diego Health

Viral infections and space travel similarly trigger inflammation and the enzymes APOBEC3C and ADAR1; UC San Diego researchers are developing ways to inhibit them…

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These are leukemia cells expressing the enzymes APOBEC3C and ADAR1.
Since stem cells can continually self-regenerate, making more stem cells, and differentiate into many different specialized cell types, they play an important role in our development and health. But there can also be a dark side — stem cells can sometimes become cancer stem cells, proliferating out of control and leading to blood cancers, such as leukemia and multiple myeloma. The self-renewing nature of cancer stem cells makes…

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