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The first mouse model of human pancreas cancer subtypes – EurekAlert

Organoids power the first mouse model of two pancreas cancer subtypes, identifying genes influencing a lethal transformation of one subtype to the other.

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IMAGE: Researchers discovered that pancreas cancer subtypes can switch between a slow-growing type and another more invasive and deadly form. This image shows human pancreas tumor “organoids ” (five large circular structures)….
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Credit: Miyabayashi/Tuveson lab, CSHL
Scientists at Cold Spring Harbor Laboratory (CSHL) have created the first mouse model of pancreatic cancer that recreates two subtypes of the human disease. The model, published July 23, 2020 in Cancer Discovery, will…

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