Health
The drug aprotinin inhibits entry of SARS-CoV2 in host cells – EurekAlert
In order for the SARS-CoV2 virus to enter host cells, its ”spike” protein has to be cleaved by the cell’s own enzymes – proteases. The protease inhibitor aprotinin…
FRANKFURT. The surface of the SARS-CoV-2 virus is studded with spike proteins. The virus needs these in order to dock onto proteins (ACE2 receptors) on the surface of the host cell. Before this docking is possible, parts of the spike protein have to be cleaved by the host cell’s enzymes – proteases.
In cell culture experiments with various cell types, the international scientific team led by Professor Jindrich Cinatl, Institute for Medical Virology at the University Hospital Frankfurt, Professor…
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