Study finds combination therapy suppresses pancreatic tumor growth in mice – Medical Xpress

UCLA Jonsson Comprehensive Cancer Center researchers have uncovered a potential new way to target pancreatic tumors that express high intratumoral interferon signaling (IFN). The team found that high type I IFN signaling is present in a subset of pancreatic tumors and it triggers a decrease in the level of NAD and NADH in pancreatic cancer cells, which are vital cofactors in critical metabolic processes.
After the researchers delineated the mechanism by which the NAD depletion occurs, they demonstrated…

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