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Stirring up conflicts in tumour cells – EurekAlert

With two commercially available inhibitors, the cell cycle of the cancer cells in the childhood tumour neuroblastoma can be disrupted at a key point causing tumour…

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IMAGE: Survival curve of the TH-MYCN mouse model during long-term treatment with Aurora-A inhibitor (purple), ATR inhibitor (blue) or the combination of both agents (red). It is clearly visible that the…
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Credit: Gabriele Buechel / University of Wuerzburg
Neuroblastomas are malignant solid tumours that occur mainly in early childhood. They arise from degenerated immature cells of the sympathetic nervous system.
One prognostic marker to assess the malignancy of the tumour is the MYCN…

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