Health
Stable spike protein makes main SARS-CoV-2 variant more infectious – The Science Board
A new study finds that the enhanced infectivity of the dominant G614 variant of the SARS-CoV-2 virus largely results from the increased stability of its spike protein….
The SARS-CoV-2 spike (S) protein is processed by a furin-like protease into the receptor-binding fragment S1 and the fusion fragment S2. Engagement of the receptor-binding domain (RBD) in S1 with the viral receptor angiotensin converting enzyme 2 (ACE2) on the surface of the host cells is followed by a second proteolytic cleavage within S2.
As a result, the S protein undergoes large conformational changes, resulting in the dissociation of S1 and irreversible refolding of S2 into a postfusion structure….
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