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Spike protein fusion loop controls SARS-CoV-2 fusogenicity and infectivity – DocWire News
J Struct Biol. 2021 Mar 1:107713. doi: 10.1016/j.jsb.2021.107713. Online ahead of print.ABSTRACTThe high SARS-CoV-2 reproductive number driving the
J Struct Biol. 2021 Mar 1:107713. doi: 10.1016/j.jsb.2021.107713. Online ahead of print.
ABSTRACT
The high SARS-CoV-2 reproductive number driving the COVID-19 pandemic has been a mystery. Our recent in vitro, and in vivo coronaviral pathogenesis studies involving Mouse Hepatitis Virus (MHV-A59) suggest a crucial role for a small host membrane-virus contact initiator region of the Spike protein, called the fusion peptide that enhances the virus fusogenicity and infectivity. Here we study the Spike…
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