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Small molecule takes aim at the RNA of SARS-CoV-2 – Chemical & Engineering News

Though far from the clinic, a two-part compound tags viral RNA for destruction by enzymes

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Scientists have identified a potential target for therapeutics against SARS-CoV-2, the virus that causes COVID-19. The discovery hinges on a small molecule that latches onto and inhibits a structure in the SARS-CoV-2 RNA genome, preventing the virus from pumping out the proteins it uses to replicate and infect cells (ACS Cent. Sci. 2020, DOI: 10.1021/acscentsci.0c00984). Although it may take years before any therapeutic could be developed from the proof-of-concept work, the approach could be hel…

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