Single-shot 3-D wide-field fluorescence imaging with a computational miniature mesoscope – Phys.org

The online feature cover photograph on Science Advances this week displays fluorescence imaging with a computational miniature mesoscope (CM2). The technique of fluorescence imaging is an essential tool for biologists and neuroscientists; however, conventional microscopes and miniaturized microscopes (miniscopes) are constrained by limited space-bandwidth producta measurement of the information capacity of an optical system, shallow depth of field and an inability to resolve three-dimensional (3-D)…

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