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Single-Cell, Spatial Analysis Creates COVID-19 Tissue Atlases – Genetic Engineering & Biotechnology News

Single-cell, spatial analysis of autopsy samples from patients who succumbed to COVID-19 offers key insights into systemic disease progression.

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Despite the enormous effort by the scientific community to understand the toll SARS-CoV-2 infection takes on the lungs and other organs, little is known about the pathophysiology of the disease. Now, a collaborative team has developed a foundational dataset consisting of tissue atlases that elucidate the biological impact of severe SARS-CoV-2 infection in the body. In this work, scientists use spatial analysis to reveal how infected cells from multiple organs exhibit a range of molecular and genomic…

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