Health
Single-cell RNAseq differentiates cancer stem cells from healthy stem cells – The Science Board
Researchers have described a new single-cell RNA-sequencing approach, leveraging genomic and mitochondrial DNA mutations, that has the potential to differentiate…
Acute myeloid leukemia is a good model to study cancer stem cells because 10%-20% of individuals over the age of 70 develop preleukemic mutations in hematopoietic stem cells. From here, the preleukemic stem cells can give rise to healthy blood and immune cells, but the acquisition of additional mutations could result in malignant expansion of aberrant leukemic stem cells.
These cancer stem cells can fuel long-term cancer growth with their ability to continuously regenerate. However, low division…
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