Science
Single-cell damagenome profiling unveils vulnerable genes and functional pathways in human genome toward DNA damage – Science Advances
We report a novel single-cell whole-genome amplification method (LCS-WGA) that can efficiently capture spontaneous DNA damage…
INTRODUCTION
As one of the major sources of DNA lesions, spontaneous DNA damage is known to be associated with mutagenesis (14). Recent studies have also suggested that spontaneous DNA damage could alter the epigenetic landscape and gene expression (5,…
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