Severe acute respiratory syndrome‐coronavirus‐2 spike (S) protein based vaccine candidates: State of the art and future prospects – Wiley

1 INTRODUCTION
Coronaviruses (CoVs) are enveloped viruses of the Coronaviridae family, composed of a large singlestrand, positivesense RNA genome (ranging from 26 to 32 kilobases in length) with 5cap and 3 polyA tail.1 While some members of the Coronaviridae family might cause mild respiratory symptoms (229E, OC43, NL63 and HKU1), three members including severe acute respiratory syndromeCoV (SARSCoV), Middle East respiratory syndromeCoV (MERSCoV) and the novel coronavirus (SARSCoV2) are highly …

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