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Scientists use cryo-electron microscopy to unravel how the ‘guardian’ of the genome works – News-Medical.net

Scientists from the Genomic Integrity and Structural Biology Group led by Rafael Fernández-Leiro at the Spanish National Cancer Research Centre have discovered…

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Scientists from the Genomic Integrity and Structural Biology Group led by Rafael Fernández-Leiro at the Spanish National Cancer Research Centre (CNIO) have discovered how certain proteins ensure the repair of errors introduced into the DNA during its replication. Using cryo-electron microscopy, they made the MutS protein, also known as the guardian of our genome, visible. That enabled them to describe how this single protein is able to coordinate the essential DNA repair process from beginning to…

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