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SARS-CoV-2 ORF7a mutation limits host immune suppression, finds study – News-Medical.Net
Researchers have identified a high variability in the C-terminal end of ORF7a in SARS-CoV-2 sequences collected from around the globe. They noted that mutations…
Besides the highly publicized spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a number of other accessory proteins belonging to the virus are involved in pathogenesis by suppressing or evading the host immune response.
One such protein is open reading frame 7a (ORF7a), which has previously been implicated in interferon antagonism and may be involved in triggering the expression of pro-inflammatory cytokines.
A new study by researchers at Montana State University in…
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