Health
SARS‐CoV‐2: Mechanism of infection and emerging technologies for future prospects – Wiley
The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has spread globally to over 200 countries with more than 23 million confirmed cases and at least 800,000 fatalities …
3.1 Mechanism of SARSCoV2 entry and infection
The binding of CoVs to host cell surface receptors and membrane fusion processes are mediated by the Spike (S) protein composed of two subunits (S1 and S2).3 In the case of SARSCoV2, the cleavage and activation of S protein are governed by the intracellular protease TMPRSS2 to generate unlocked, fusioncatalysed forms on the cell surface. This promotes the early entry of the virus.40 Albeit some differences in the aa sequences of SARSCoV2 and SARSCoV…
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