Safeguarding of key DNA sensor in innate immune system – Science Daily

UNC-Chapel Hill researchers have, for the first time, determined the high-resolution structure of a key DNA-sensing protein in the innate immune system called cGAS while it is bound to the nucleosome — the all-important unit of DNA packaging inside a cell’s nucleus.This research, published in Science, reveals in detail how the nucleosomes inside our cells block cGAS from unintentionally triggering the body’s innate immune response to our own DNA. The work was led by Qi Zhang, PhD, associate pro…

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