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Retracing the history of the mutation that gave rise to cancer decades later – Science Daily

Researchers reconstructed the evolutionary history of cancer cells in two patients, tracing the timeline of the mutation that causes the disease to a cell of origin….

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There is no stronger risk factor for cancer than age. At the time of diagnosis, the median age of patients across all cancers is 66. That moment, however, is the culmination of years of clandestine tumor growth, and the answer to an important question has thus far remained elusive: When does a cancer first arise?At least in some cases, the original cancer-causing mutation could have appeared as long as 40 years ago, according to a new study by researchers at Harvard Medical School and the Dana-Farber…

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