Researchers reveal safeguarding of key DNA sensor in innate immune system. – Brinkwire

UNC-Chapel Hill researchers have, for the first time, determined the high-resolution structure of a key DNA-sensing protein in the innate immune system called cGAS while it is bound to the nucleosomethe all-important unit of DNA packaging inside a cell’s nucleus.
This research, published in Science, reveals in detail how the nucleosomes inside our cells block cGAS from unintentionally triggering the body’s innate immune response to our own DNA. The work was led by Qi Zhang, Ph.D., associate pro…

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