Health
Researchers discover balance between two protein counteracting forces in hereditary ataxias – Medical Xpress
Collaborating with the University of Oxford, Professor Ho Yin Edwin Chan’s research team from the School of Life Sciences of The Chinese University of Hong Kong…
Prpf19 is capable of degrading toxic expanded SCA3-polyQ proteinProfessor Edwin Chan, Postdoctoral Fellow Dr. Zhefan Stephen Chen, and the team discovered that the nuclear-localized protein Prpf19 is responsible for scrutinizing the quality of SCA3-polyQ, the disease protein of SCA3 or MJD. Potentiating the function of Prpf19 promotes degradation of faculty SCA3-polyQ protein via a process called ubiquitin-proteasome degradation. In this, the toxicity of SCA3 cells is proved to be alleviated, and…
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