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Researchers discover balance between two protein counteracting forces in hereditary ataxias – Medical Xpress

Collaborating with the University of Oxford, Professor Ho Yin Edwin Chan’s research team from the School of Life Sciences of The Chinese University of Hong Kong…

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Prpf19 is capable of degrading toxic expanded SCA3-polyQ proteinProfessor Edwin Chan, Postdoctoral Fellow Dr. Zhefan Stephen Chen, and the team discovered that the nuclear-localized protein Prpf19 is responsible for scrutinizing the quality of SCA3-polyQ, the disease protein of SCA3 or MJD. Potentiating the function of Prpf19 promotes degradation of faculty SCA3-polyQ protein via a process called ubiquitin-proteasome degradation. In this, the toxicity of SCA3 cells is proved to be alleviated, and…

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