Health
Research uncovers potential cause of neurotoxicity due to immunotherapy – News-Medical.Net
New research has uncovered the previously unknown presence of CD19 — a B cell molecule targeted by chimeric antigen receptor (CAR) T cell immunotherapy to treat leukemia, lymphoma, and multiple myeloma — in brain cells that protect the blood brain barrier (…
Reviewed by Emily Henderson, B.Sc.Sep 21 2020
New research has uncovered the previously unknown presence of CD19 — a B cell molecule targeted by chimeric antigen receptor (CAR) T cell immunotherapy to treat leukemia, lymphoma, and multiple myeloma — in brain cells that protect the blood brain barrier (BBB).
This discovery may potentially be the cause for neurotoxicity in patients undergoing CD19 directed CAR T cell immunotherapy, according to the research team led by Avery Posey, PhD, an ass…
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