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Regulatory CD4+ and CD8+ T cells are negatively correlated with CD4+/CD8+ T cell ratios in patients acutely infected with SARS‐CoV‐2 – Wiley

Regulatory CD4+ and CD8+ T cells are negatively correlated with CD4+/CD8+ T cell ratios in patients acutely infected with SARS‐CoV‐2

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1 INTRODUCTION
Lymphocytopenia caused by acute virus infections have been suggested to be associated with increased risks of infectionrelated hospitalization and death.1-4 Similar observations have also been reported in COVID19 patients, but not all cell subsets of peripheral blood lymphocytes were reduced.5-7 Of note, multiple studies observed the decrease of T cells consistently in the peripheral blood of COVID19 patients.8-11 Increased inflammatory infiltration in lungs may partially account…

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