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Polθ reverse transcribes RNA and promotes RNA-templated DNA repair – Science Advances
Genome-embedded ribonucleotides arrest replicative DNA polymerases (Pols) and cause DNA breaks. Whether mammalian DNA repair…
INTRODUCTION
Polymerase (Pol) is a unique DNA polymerase-helicase fusion protein in higher eukaryotes whose A-family polymerase domain evolved from Pol I enzymes (Fig. 1A) (1, 2). However, contrary to most Pol I enzymes, Pol is highly error-prone and promiscuous…
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