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Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients – DocWire News
J Exp Med. 2020 Dec 7;217(12):e20200872. doi: 10.1084/jem.20200872.ABSTRACTCOVID-19 includes lung infection ranging from mild pneumonia to
J Exp Med. 2020 Dec 7;217(12):e20200872. doi: 10.1084/jem.20200872.
ABSTRACT
COVID-19 includes lung infection ranging from mild pneumonia to life-threatening acute respiratory distress syndrome (ARDS). Dysregulated host immune response in the lung is a key feature in ARDS pathophysiology. However, cellular actors involved in COVID-19-driven ARDS are poorly understood. Here, in blood and airways of severe COVID-19 patients, we serially analyzed unconventional T cells, a heterogeneous class of T…
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