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New study uncovers potential therapeutic target for lupus – News-Medical.Net
A recent study published in JCI found that a neutrophil’s endoplasmic reticulum, the organelle that normally makes proteins in the cell, becomes stressed in the…
A recent study published in JCI found that a neutrophil’s endoplasmic reticulum, the organelle that normally makes proteins in the cell, becomes stressed in the autoimmune disorder lupus. This stress activates a molecule called IRE1α, which appears to play a critical role in lupus pathogenesis in mice.
A multidisciplinary research group at the University of Michigan, spanning microbiology, dermatology and rheumatology, discovered that IRE1α orchestrates the release of neutrophil extracellular traps,…
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