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New studies report specific mechanisms of impaired type I interferon signaling in COVID-19 patients – News-Medical.Net

Two new studies report specific mechanisms of impaired type I interferon (IFN) signaling in some hospitalized patients suffering from severe cases of COVID-19, suggesting that screens for these defects could help identify patients at the highest risk of life-…

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Reviewed by Emily Henderson, B.Sc.Sep 25 2020
Two new studies report specific mechanisms of impaired type I interferon (IFN) signaling in some hospitalized patients suffering from severe cases of COVID-19, suggesting that screens for these defects could help identify patients at the highest risk of life-threatening complications from SARS-CoV-2 infection.
The results of the paired studies – which report that mutations in type I IFN-associated genes and high titers of neutralizing autoantibodie…

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