New mutations accumulate in reproductive cells of older mice – Mirage News

Older mice have more new mutations in the genomes of their mitochondria than young mice. Researchers compared the DNA sequence of mitochondrial genomes from muscle cells, brain cells, and single female reproductive cells-oocytes (left) using an extremely accurate DNA sequencing technology called duplex sequencing (center) and found that mutations accumulated during the lifetime of the older mice (right).
Image: Barbara Arbeithuber
Older mice have more new mutations – changes in DNA sequence th…

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