Health
New Information Uncovered on the Action of Antidepressants – Technology Networks
The findings of a new study challenge the prevailing thinking on the primary role of serotonin and other neurotransmitters in the effects of antidepressants.
Neurotrophic factors regulate the development and plasticity of the nervous system. While all antidepressants increase the quantity and signalling of brain-derived neurotrophic factor (BDNF) in the brain, the drugs have so far been thought to act on BDNF indirectly, through serotonin or glutamate receptors.
A new study published this week in Cell demonstrates, however, that antidepressants bind directly to a BDNF receptor known as TrkB. This finding challenges the primary role of serotonin or glutamate…
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