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New Algorithm Reveals How Tumors Evolve During Their Lifetime – Technology Networks

A new algorithmic approach reveals individual tumors continue to evolve and remodel their genomes, and this occurs across a broad range of tumor types. Identifying changes that benefit tumors and help them metastasize could help with future treatments.

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Cancers gain and lose large sections of chromosomes in some of their cells but not in others, a process that may indicate ongoing evolution and selection for preferred traits, report a team of researchers led by the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), The Francis Crick Institute and the University College London. The finding, published in the journal Nature, was prevalent in 22 tumor types, including breast cancer, colorectal cancer and lung cancer.
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