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Neuropilin 1: A novel entry factor for SARS-CoV-2 infection | BTT – Dove Medical Press
An overview of SARS-CoV-2 entry mechanisms, the structure of NRP1, and their roles in health and various diseases
Introduction
Neuropilin 1 (NRP1) is one of two homologous neuropilins (NRP) expressed in all vertebrates that has important physiological and pathological roles.1 It was identified first in 1987 by Takagi and his coworkers as a neuronal receptor in developing Chick nervous system.2 NRP1 can exist in two isoforms, namely, secretory and transmembrane isoforms.3,4 The former, also known as truncated or soluble NRP1, circulates freely in the body fluid, whereas the latter isoform, transmembrane NRP1,…
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