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Minimally instrumented SHERLOCK (miSHERLOCK) for CRISPR-based point-of-care diagnosis of SARS-CoV-2 and emerging variants – Science Advances

The COVID-19 pandemic highlights the need for diagnostics that can be rapidly adapted and deployed in a variety of settings….

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INTRODUCTION
Substantial progress has been made in the use of CRISPR (clustered regularly interspaced short palindromic repeats)/Cas components of adaptive microbial immunity in molecular diagnostics (13). Several Cas effectors have been used as highly…

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