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MAIT cell activation and dynamics associated with COVID-19 disease severity – Science

Severe COVID-19 is characterized by excessive inflammation of the lower airways. The balance of protective versus pathological immune responses in COVID-19 is i…

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INTRODUCTION
Severe acute respiratory syndrome (SARS) Coronavirus-19 (SARS-CoV-2) causes viral pneumonia and coronavirus disease 2019 (COVID-19), which in some individuals progresses to acute respiratory distress syndrome (ARDS) characterized by aggressive inflammatory responses in the lower airways (reviewed in (1)). Severe COVID-19 is not only due to direct effects of the virus, but also in part to a misdirected host response with complex immune dysregulation of both innate and adaptive immun…

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