Health
Long-range allosteric influences on SARS-COV-2-ACE2 stability and detachment – News-Medical.Net
The COVID-19 pandemic is caused by SARS-CoV-2, a novel beta-coronavirus which has numerous spike proteins on its membrane.
The COVID-19 pandemic is caused by SARS-CoV-2, a novel beta-coronavirus which has numerous spike proteins on its membrane. These are responsible for its engagement with the angiotensin-converting enzyme 2 (ACE2), the host cell receptor.
Image Credit: https://www.biorxiv.org/content/10.1101/2020.11.30.405340v1.full.pdf
The spike tip exists in both ‘up’ and ‘down’ conformations. In the former, the homotrimeric spike protein exposes the receptor-binding domain (RBD) so that it can attach to the host….
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