Health
In Pancreatic Cancer, New Biomarker May Predict Benefit of Tumor-Penetrating Peptide – Genetic Engineering & Biotechnology News
Study of pancreatic cancer identified biomarker that may indicate which patients would respond best to combination therapies incorporating a tumor-penetrating peptide….
Hunkered behind a dense layer of fibrotic tissue, pancreatic tumors stubbornly resist the delivery of therapeutic molecules. Yet this barrier, this desmoplastic tumor tissue, can be penetrated by iRGD, a nine-amino-acid cyclic peptide. In experiments with models of pancreatic cancer, specifically, mouse models and organoids, iRGD was found to penetrate tumors via a molecular pathway mediated by 5 integrin, a protein that is produced by carcinoma-associated fibroblasts (CAFs). This newfound role…
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