Science
How cGAS is kept bottled up – Mirage News
In higher organisms, detection of DNA in the cytoplasm triggers an immune reaction. The enzyme that senses ‘misplaced’ DNA is also found in the nucleus,…
In higher organisms, detection of DNA in the cytoplasm triggers an immune reaction. The enzyme that senses ‘misplaced’ DNA is also found in the nucleus, but nuclear DNA has no such effect. LMU researchers now report why that is so.The bulk of the DNA in the cells of higher organisms is confined to the nucleus, while all other organellar DNAs are restricted to defined intracellular compartments in the cytoplasm. The appearance of DNA in the soluble phase of the cytoplasm is therefore interpreted …
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