Genetic cause of congenital malformation discovered – Medical Xpress

Spontaneous mutations of a single gene are likely to cause serious developmental disorders of the excretory organs and genitalia. This is shown in an international study led by the University of Bonn and published in the journal Frontiers in Cell and Developmental Biology. The researchers also owe their findings to an unusual model organism: the zebrafish.
One in 10,000 newborns is born with malformations of the bladder, intestines or genitals. These symptoms are part of the so-called bladder e…

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