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Eliminating key gene could revive exhausted immune cells to battle solid tumors – News-Medical.Net

Eliminating a single gene can turn exhausted cancer-fighting immune cells known as CD8+ T cells back into refreshed soldiers that can continue to battle malignant…

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Eliminating a single gene can turn exhausted cancer-fighting immune cells known as CD8+T cells back into refreshed soldiers that can continue to battle malignant tumors, a new study led by UT Southwestern researchers suggests. The findings, published online this week in the Journal for Immunotherapy of Cancer, could offer a new way to harness the body’s immune system to attack cancers.
In 2017, the Food and Drug Administration approved treatments involving chimeric antigen receptor T (CAR-T) cells,…

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