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Dementia: Cholesterol breakdown in the brain plays key role – Medical News Today

New research suggests that, in males, the breakdown of cholesterol in the brain plays an important role in the progression of dementia.

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  • There is a well-established connection between high cholesterol levels in the blood and dementia. However, cholesterol cannot cross the blood-brain barrier, so its link with dementia is hard to explain.
  • A new study suggests that bile acids, the breakdown products of cholesterol, are detectable in the brain and play a vital role in healthy brain function.
  • The research found that low levels of these molecules in the brain were associated with a more rapid progression of dementia in males.
  • The study…

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