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Decreasing activity of ZMPSTE24 protease with age and comorbidities may make elderly COVID-19 patients vulnerable – News-Medical.Net

Studies have shown that circulating levels of PAI-1, the coagulation cascade activator, are considerably higher in COVID-19 patients with severe respiratory illness…

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Endothelial dysfunction is a feature of thrombotic events reported in COVID-19 disease patients. However, the underlying molecular mechanisms of COVID-19-induced endothelial dysfunction are not clear.
Studies have shown that circulating levels of PAI-1, the coagulation cascade activator, are considerably higher in COVID-19 patients with severe respiratory illness compared to patients with bacterial-sepsis and acute respiratory distress syndrome (ARDS). Hence the increase in PAI-1 levels is recognized…

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