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Cytokines may prevent COVID-19 patients from producing the ‘best’ antibodies – The Science Board

High levels of some cytokines associated with COVID-19 could prevent long-term antibody responses to the SARS-CoV-2 virus, according to a new study published in Cell on August 19. The findings could explain why immunity to the novel coronavirus does …

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Studies in convalescent COVID-19 patients indicate that humoral immunity is often short-lived, and most SARS-CoV-2 antibodies exhibit limited somatic hypermutation — adaptation to new foreign elements.
“We’ve seen a lot of studies suggesting that immunity to COVID-19 is not durable because the antibodies decline over time,” said co-senior author Dr. Shiv Pillai, PhD, professor at Harvard Medical School and member of the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute…

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